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Prior to initiating treatment of gastric ulcer, any possibility of malignancy should first be excluded as Omeprazole therapy may mask the symptoms and delay diagnosis.
Omeprazole inhibits the metabolism of several drugs which are metabolized through the cytochrome P-450 enzyme system of the liver and may enhance the plasma concentration of diazepam, phenytoin and warfarin.
Patients with impaired hepatic function: Significant increase in bioavailability, reduction of total plasma clearance and prolonged half-life up to 4 times the normal values are observed in patients with impaired liver function. However, urinary recovery within 96 hours is still unchanged, indicating that there is no accumulation of Omeprazole or its metabolites.
